AustralieFrV1, Main, Exploration, bibRecord, 006816

Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants

Identifieur interne : 006816 ( Main/Exploration ); précédent : 006815; suivant : 006817

Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants

Auteurs : Judith Trotman ; Marion Fournier [France] ; Thierry Lamy [France] ; John Francis Seymour [Australie] ; Anne Sonet [France] ; Andrea Janikova [République tchèque] ; Ofer Shpilberg [Israël] ; Emmanuel Gyan [France] ; Hervé Tilly [France] ; Jane Estell ; Cecily Forsyth [Australie] ; Didier Decaudin [France] ; Bettina Fabiani [France] ; Jean Gabarre [France] ; Bruno Salles [France] ; Eric Van Den Neste [Belgique] ; Danielle Canioni [France] ; Etienne Garin [France] ; Michael Fulham [Australie] ; Thierry Vander Borght [France] ; Gilles Salles [France]

Source :

Journal of clinical oncology [ 0732-183X ] ; 2011.

RBID : Pascal:11-0380678

Descripteurs français

Pascal (Inist)
- Tomoscintigraphie, Tomographie par émission de positons, Traitement induction, Tomodensitométrie, Homme, Pronostic, Lymphome folliculaire, Essai clinique, Cancérologie, Hémopathie maligne lymphoïde, Hémopathie lymphoïde B.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- B cell neoplasm, Cancerology, Clinical trial, Computerized axial tomography, Emission tomography, Follicular lymphoma, Human, Induction treatment, Lymphoid neoplasm, Positron emission tomography, Prognosis.

Abstract

Purpose The utility of [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Patients and Methods Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Results Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT-positive (PET-positive) and PET-CT-negative (PET-negative) patients. PET status correlated with conventional response criteria (P<.001). Patients remaining PET positive had a significantly (P< .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). Conclusion [¹⁸F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.

Affiliations:

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Le document en format XML

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<country>France</country>
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<settlement type="city">Rouen</settlement>
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<author><name sortKey="Estell, Jane" sort="Estell, Jane" uniqKey="Estell J" first="Jane" last="Estell">Jane Estell</name>
<affiliation><inist:fA14 i1="01"><s1>Concord Hospital</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wyong Hospital</s1>
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<sZ>11 aut.</sZ>
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<country>Australie</country>
<wicri:noRegion>Wyong Hospital</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institut Curie</s1>
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<country>France</country>
<wicri:noRegion>Institut Curie</wicri:noRegion>
<wicri:noRegion>Institut Curie</wicri:noRegion>
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</author>
<author><name sortKey="Fabiani, Bettina" sort="Fabiani, Bettina" uniqKey="Fabiani B" first="Bettina" last="Fabiani">Bettina Fabiani</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine</s1>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
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<country>France</country>
<wicri:noRegion>Hôpital Saint-Antoine</wicri:noRegion>
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<author><name sortKey="Gabarre, Jean" sort="Gabarre, Jean" uniqKey="Gabarre J" first="Jean" last="Gabarre">Jean Gabarre</name>
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<country>France</country>
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<country>France</country>
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</author>
<author><name sortKey="Den Neste, Eric Van" sort="Den Neste, Eric Van" uniqKey="Den Neste E" first="Eric Van" last="Den Neste">Eric Van Den Neste</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>UCL Saint-Luc</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>16 aut.</sZ>
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<country>Belgique</country>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
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</affiliation>
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<author><name sortKey="Canioni, Danielle" sort="Canioni, Danielle" uniqKey="Canioni D" first="Danielle" last="Canioni">Danielle Canioni</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Hôpital Necker</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garin, Etienne" sort="Garin, Etienne" uniqKey="Garin E" first="Etienne" last="Garin">Etienne Garin</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU de Rennes</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fulham, Michael" sort="Fulham, Michael" uniqKey="Fulham M" first="Michael" last="Fulham">Michael Fulham</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Borght, Thierry Vander" sort="Borght, Thierry Vander" uniqKey="Borght T" first="Thierry Vander" last="Borght">Thierry Vander Borght</name>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Universite Catholique de Louvain (UCL), Mont-Godinne Medical Center</s1>
<s2>Yvoir</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
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<country>France</country>
<wicri:noRegion>Yvoir</wicri:noRegion>
<wicri:noRegion>Mont-Godinne Medical Center</wicri:noRegion>
<wicri:noRegion>Yvoir</wicri:noRegion>
<orgName type="university">Université catholique de Louvain</orgName>
<placeName><settlement type="city">Louvain-la-Neuve</settlement>
<region type="region" nuts="1">Région wallonne</region>
<region type="province" nuts="1">Province du Brabant wallon</region>
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<author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Hospices Civils de Lyon, Universite Lyon1</s1>
<s3>FRA</s3>
<sZ>21 aut.</sZ>
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<country>France</country>
<wicri:noRegion>Universite Lyon1</wicri:noRegion>
<wicri:noRegion>Hospices Civils de Lyon, Universite Lyon1</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>B cell neoplasm</term>
<term>Cancerology</term>
<term>Clinical trial</term>
<term>Computerized axial tomography</term>
<term>Emission tomography</term>
<term>Follicular lymphoma</term>
<term>Human</term>
<term>Induction treatment</term>
<term>Lymphoid neoplasm</term>
<term>Positron emission tomography</term>
<term>Prognosis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tomoscintigraphie</term>
<term>Tomographie par émission de positons</term>
<term>Traitement induction</term>
<term>Tomodensitométrie</term>
<term>Homme</term>
<term>Pronostic</term>
<term>Lymphome folliculaire</term>
<term>Essai clinique</term>
<term>Cancérologie</term>
<term>Hémopathie maligne lymphoïde</term>
<term>Hémopathie lymphoïde B</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose The utility of [<sup>18</sup>
F]fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Patients and Methods Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Results Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT-positive (PET-positive) and PET-CT-negative (PET-negative) patients. PET status correlated with conventional response criteria (P<.001). Patients remaining PET positive had a significantly (P< .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). Conclusion [<sup>18</sup>
F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>France</li>
<li>Israël</li>
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<orgName><li>Université catholique de Louvain</li>
<li>Université de Melbourne</li>
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<tree><noCountry><name sortKey="Estell, Jane" sort="Estell, Jane" uniqKey="Estell J" first="Jane" last="Estell">Jane Estell</name>
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<name sortKey="Decaudin, Didier" sort="Decaudin, Didier" uniqKey="Decaudin D" first="Didier" last="Decaudin">Didier Decaudin</name>
<name sortKey="Fabiani, Bettina" sort="Fabiani, Bettina" uniqKey="Fabiani B" first="Bettina" last="Fabiani">Bettina Fabiani</name>
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<name sortKey="Gyan, Emmanuel" sort="Gyan, Emmanuel" uniqKey="Gyan E" first="Emmanuel" last="Gyan">Emmanuel Gyan</name>
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<name sortKey="Salles, Bruno" sort="Salles, Bruno" uniqKey="Salles B" first="Bruno" last="Salles">Bruno Salles</name>
<name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name>
<name sortKey="Sonet, Anne" sort="Sonet, Anne" uniqKey="Sonet A" first="Anne" last="Sonet">Anne Sonet</name>
<name sortKey="Tilly, Herve" sort="Tilly, Herve" uniqKey="Tilly H" first="Hervé" last="Tilly">Hervé Tilly</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John Francis" sort="Seymour, John Francis" uniqKey="Seymour J" first="John Francis" last="Seymour">John Francis Seymour</name>
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<name sortKey="Forsyth, Cecily" sort="Forsyth, Cecily" uniqKey="Forsyth C" first="Cecily" last="Forsyth">Cecily Forsyth</name>
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</country>
<country name="République tchèque"><region name="Moravie"><name sortKey="Janikova, Andrea" sort="Janikova, Andrea" uniqKey="Janikova A" first="Andrea" last="Janikova">Andrea Janikova</name>
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<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Den Neste, Eric Van" sort="Den Neste, Eric Van" uniqKey="Den Neste E" first="Eric Van" last="Den Neste">Eric Van Den Neste</name>
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Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants

Positron Emission Tomography-Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants

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